Structure of PDB 6ip5 Chain 2i

Receptor sequence

>6ip52i (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]

VNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQ
TKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKG
QVIQF

3D structure

PDB

6ip5 HCV IRES Captures an Actively Translating 80S Ribosome.

Chain

Resolution

3.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2i	V2 N3 P5 R8 R9 T10 F11 K13 K14 H18 Y26 G29 S32 A35 Q36 G37 R39 R40 R43 K44 G47 Y48 K53 P54 I55 F56 R57 K59 A60 K61 K65 V67 K80 R81 M82 K86 R87 C88 K89 K97	V1 N2 P4 R7 R8 T9 F10 K12 K13 H17 Y25 G28 S31 A34 Q35 G36 R38 R39 R42 K43 G46 Y47 K52 P53 I54 F55 R56 K58 A59 K60 K64 V66 K79 R80 M81 K85 R86 C87 K88 K96
BS02	rna	2i	Y41 K53 P54 I55 F56	Y40 K52 P53 I54 F55

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6ip5, PDBe:6ip5, PDBj:6ip5
PDBsum	6ip5
PubMed	31080011
UniProt	P83881\|RL36A_HUMAN Large ribosomal subunit protein eL42 (Gene Name=RPL36A)