Structure of PDB 8vtx Chain 2g

Receptor sequence

>8vtx2g (length=155) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

ARRRRAEVRQLQPDLVYGDVLVTAFINKIMRDGKKNLAARIFYDACKIIQ
EKTGQEPLKVFKQAVENVKPRMEVRSRRVGGANYQVPMEVSPRRQQSLAL
RWLVQAANQRPERRAAVRIAHELMDAAEGKGGAVKKKEDVERMAEANRAY
AHYRW

3D structure

PDB

8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2g	A2 R3 R4 R6 A7 R10 N28 K29 I30 M31 R32 D33 G34 K35 K36 N37 L38 R41 I42 R79 R94 R95 S98 R102 N109 R114 R115 A116 R119	A1 R2 R3 R5 A6 R9 N27 K28 I29 M30 R31 D32 G33 K34 K35 N36 L37 R40 I41 R78 R93 R94 S97 R101 N108 R113 R114 A115 R118
BS02	rna	2g	Q86 R143 M144 A147	Q85 R142 M143 A146

External links

PDB	RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum	8vtx
PubMed	39039256
UniProt	P17291\|RS7_THET8 Small ribosomal subunit protein uS7 (Gene Name=rpsG)

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