Structure of PDB 9b00 Chain 2e

Receptor sequence

>9b002e (length=148) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

DFEEKMILIRRTARMQAGGRRFRFGALVVVGDRQGRVGLGFGKAPEVPLA
VQKAGYYARRNMVEVPLQNGTIPHEIEVEFGASKIVLKPAAPGTGVIAGA
VPRAILELAGVTDILTKELGSRNPINIAYATMEALRQLRTKADVERLR

3D structure

PDB

9b00 Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity.

Chain

Resolution

2.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2e	R14 T16 A17 R18 M19 Q20 G22 R24 R25 R27 F45 K47 P49 K57 F84 G85 A86 K92 A94 A95 T98 I101 A102 R107 L119 T120 K121 E122 L123 S125 R126 N127 N130	R10 T12 A13 R14 M15 Q16 G18 R20 R21 R23 F41 K43 P45 K53 F80 G81 A82 K88 A90 A91 T94 I97 A98 R103 L115 T116 K117 E118 L119 S121 R122 N123 N126
BS02	MG	2e	E68 D147	E64 D143

External links

PDB	RCSB:9b00, PDBe:9b00, PDBj:9b00
PDBsum	9b00
PubMed	39019034
UniProt	Q5SHQ5\|RS5_THET8 Small ribosomal subunit protein uS5 (Gene Name=rpsE)

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