Structure of PDB 8vtw Chain 2Y

Receptor sequence
>8vtw2Y (length=107) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVR
VSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCA
KCGGALD
3D structure
PDB8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain2Y
Resolution2.35 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 2Y M1 K4 H6 K8 K9 S17 G18 K19 V30 P32 Y35 K46 K47 A48 V49 R50 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95 M1 K4 H6 K8 K9 S17 G18 K19 V30 P32 Y35 K46 K47 A48 V49 R50 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95
BS02 ZN 2Y C76 C79 C99 C102 C76 C79 C99 C102
External links
PDB RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum8vtw
PubMed39039256
UniProtQ5SHP9|RL24_THET8 Large ribosomal subunit protein uL24 (Gene Name=rplX)

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