Structure of PDB 8vtv Chain 2Y

Receptor sequence

>8vtv2Y (length=107) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MRVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVR
VSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCA
KCGGALD

3D structure

PDB

8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.55 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2Y	M1 R2 K4 H6 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95 K101	M1 R2 K4 H6 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95 K101
BS02	ZN	2Y	C76 C79 C99 C102	C76 C79 C99 C102

External links

PDB	RCSB:8vtv, PDBe:8vtv, PDBj:8vtv
PDBsum	8vtv
PubMed	39039256
UniProt	Q5SHP9\|RL24_THET8 Large ribosomal subunit protein uL24 (Gene Name=rplX)