Structure of PDB 6ip6 Chain 2Y

Receptor sequence

>6ip62Y (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]

AALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKG
QILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAH
NVSSKNRKAIVERAAQLAIRVTNPNARL

3D structure

PDB

6ip6 HCV IRES Captures an Actively Translating 80S Ribosome.

Chain

Resolution

4.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2Y	R5 V8 K15 R16 K18 F20 R22 Q24 D26 Y28 K30 N34 W35 R36 K37 R39 G40 I41 D42 N43 R44 R47 R48 F49 K50 G51 Q52 N57 I58 G59 Y60 G61 S62 N63 K64 H68 K76 K83 E98 I99 A100 H101 N102 S104 S105 K106 N124 A127	R4 V7 K14 R15 K17 F19 R21 Q23 D25 Y27 K29 N33 W34 R35 K36 R38 G39 I40 D41 N42 R43 R46 R47 F48 K49 G50 Q51 N56 I57 G58 Y59 G60 S61 N62 K63 H67 K75 K82 E97 I98 A99 H100 N101 S103 S104 K105 N123 A126

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6ip6, PDBe:6ip6, PDBj:6ip6
PDBsum	6ip6
PubMed	31080011
UniProt	P62910\|RL32_HUMAN Large ribosomal subunit protein eL32 (Gene Name=RPL32)