Structure of PDB 8vtw Chain 2V

Receptor sequence
>8vtw2V (length=101) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MFAIVKTGGKQYRVEPGLKLRVEKLDAEPGATVELPVLLLGGEKTVVGTP
VVEGASVVAEVLGHGRGKKILVSKFKAKVQYRRKKGHRQPYTELLIKEIR
G
3D structure
PDB8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain2V
Resolution2.35 Å
3D
structure
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Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna 2V G8 G9 K10 E23 K24 K69 V72 K74 F75 K76 A77 K78 V79 Q80 Y81 R83 K84 K85 G86 H87 Q89 P90 G8 G9 K10 E23 K24 K69 V72 K74 F75 K76 A77 K78 V79 Q80 Y81 R83 K84 K85 G86 H87 Q89 P90
BS02 MG 2V E23 K24 P90 E23 K24 P90
BS03 MG 2V F75 K76 Q80 R82 F75 K76 Q80 R82
External links
PDB RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum8vtw
PubMed39039256
UniProtP60492|RL21_THET8 Large ribosomal subunit protein bL21 (Gene Name=rplU)

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