Structure of PDB 6ip6 Chain 2U

Receptor sequence

>6ip62U (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]

PSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPG
YFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPII
DVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVA

3D structure

PDB

6ip6 HCV IRES Captures an Actively Translating 80S Ribosome.

Chain

Resolution

4.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2U	P2 S3 R4 R6 K7 T8 R9 K10 R12 G13 H14 V15 S16 H17 H19 G20 R21 I22 G23 H25 R26 K27 H28 G30 G31 R32 G33 N34 G36 H39 H40 H41 R42 I43 K47 Y52 K55 G57 M58 K59 H60 Y61 H62 L63 K64 R65 Q67 N74 K77 V82 S83 Q85 T86 I100 D102 R105 K110 L112 G113 G115 K116 S130 R131 R132 K136	P1 S2 R3 R5 K6 T7 R8 K9 R11 G12 H13 V14 S15 H16 H18 G19 R20 I21 G22 H24 R25 K26 H27 G29 G30 R31 G32 N33 G35 H38 H39 H40 R41 I42 K46 Y51 K54 G56 M57 K58 H59 Y60 H61 L62 K63 R64 Q66 N73 K76 V81 S82 Q84 T85 I99 D101 R104 K109 L111 G112 G114 K115 S129 R130 R131 K135

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6ip6, PDBe:6ip6, PDBj:6ip6
PDBsum	6ip6
PubMed	31080011
UniProt	P46776\|RL27A_HUMAN Large ribosomal subunit protein uL15 (Gene Name=RPL27A)