Structure of PDB 8vtu Chain 2T

Receptor sequence

>8vtu2T (length=131) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MNRGALIKLVESRYVRTDLPEFRPGDTVRVSYKVKEGNRTRIQDFEGIVI
RIRRNGFNTTFTVRKVSYGVGVERIFPLHSPLIQKIDIVQRGRARRAKLY
FIRNLSDREIRRKLRADRKRIDQDRAAERAA

3D structure

PDB

8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2T	N2 R3 G4 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 R115 K119	N2 R3 G4 R23 R51 R53 R54 N55 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 R115 K119
BS02	rna	2T	R39 R41 Q43 S106 R108 R111 R118 R125	R39 R41 Q43 S106 R108 R111 R118 R125
BS03	MG	2T	I52 K98	I52 K98

External links

PDB	RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum	8vtu
PubMed	39039256
UniProt	P60490\|RL19_THET8 Large ribosomal subunit protein bL19 (Gene Name=rplS)