Structure of PDB 6ip6 Chain 2T

Receptor sequence

>6ip62T (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]

GKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPR
KVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVF
RDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF

3D structure

PDB

6ip6 HCV IRES Captures an Actively Translating 80S Ribosome.

Chain

Resolution

4.5 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2T	A15 G16 R17 R36 Y38 R48 R51 K52 T54 A55 K60 K64 K69 V74 Y75 N76 N78 H79 K107 R111 R112 K115 K133 R135 F136	A14 G15 R16 R35 Y37 R47 R50 K51 T53 A54 K59 K63 K68 V73 Y74 N75 N77 H78 K106 R110 R111 K114 K132 R134 F135

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:0098556	cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6ip6, PDBe:6ip6, PDBj:6ip6
PDBsum	6ip6
PubMed	31080011
UniProt	P61353\|RL27_HUMAN Large ribosomal subunit protein eL27 (Gene Name=RPL27)