Structure of PDB 8fc3 Chain 2S

Receptor sequence

>8fc32S (length=110) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

RLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSAS
SLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKALA
EGAREGGLEF

3D structure

PDB

8fc3 Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.

Chain

Resolution

2.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2S	R3 L4 A6 R9 R10 F12 R13 N16 R17 I18 T21 R23 R89 Y94 R106 F112	R1 L2 A4 R7 R8 F10 R11 N14 R15 I16 T19 R21 R87 Y92 R104 F110
BS02	rna	2S	K11 R15 K19 R25 F29 R30 S31 L32 H34 Y36 Q38 V46 T47 S50 L54 K62 T63 Y92 K93 H95 R97	K9 R13 K17 R23 F27 R28 S29 L30 H32 Y34 Q36 V44 T45 S48 L52 K60 T61 Y90 K91 H93 R95

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8fc3, PDBe:8fc3, PDBj:8fc3
PDBsum	8fc3
PubMed	37452045
UniProt	Q5SHQ4\|RL18_THET8 Large ribosomal subunit protein uL18 (Gene Name=rplR)