Structure of PDB 6ip6 Chain 2P
Receptor sequence
>6ip62P (length=131) Species:
9606
(Homo sapiens) [
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SGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGD
MVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNK
GEMKGSAITGPVAKECADLWPRIASNAGSIA
3D structure
PDB
6ip6
HCV IRES Captures an Actively Translating 80S Ribosome.
Chain
2P
Resolution
4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
rna
2P
S10 A12 R15 S17 G23 A24 V25 I40 S41 K43 G44 K46 R48 L49 N50 R51 L52 M62 T64 R85 R89 K91 F95
S1 A3 R6 S8 G14 A15 V16 I31 S32 K34 G35 K37 R39 L40 N41 R42 L43 M53 T55 R76 R80 K82 F86
Gene Ontology
Molecular Function
GO:0001223
transcription coactivator binding
GO:0003723
RNA binding
GO:0003735
structural constituent of ribosome
GO:0005515
protein binding
GO:0031625
ubiquitin protein ligase binding
GO:0070180
large ribosomal subunit rRNA binding
GO:1990948
ubiquitin ligase inhibitor activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0002181
cytoplasmic translation
GO:0006412
translation
GO:0006610
ribosomal protein import into nucleus
GO:0008284
positive regulation of cell population proliferation
GO:0010628
positive regulation of gene expression
GO:0032986
protein-DNA complex disassembly
GO:0050821
protein stabilization
GO:0070314
G1 to G0 transition
GO:0072717
cellular response to actinomycin D
GO:1901798
positive regulation of signal transduction by p53 class mediator
GO:1903450
regulation of G1 to G0 transition
GO:1904667
negative regulation of ubiquitin protein ligase activity
GO:2000059
negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005654
nucleoplasm
GO:0005730
nucleolus
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005840
ribosome
GO:0005925
focal adhesion
GO:0016020
membrane
GO:0022625
cytosolic large ribosomal subunit
GO:0022626
cytosolic ribosome
GO:0032991
protein-containing complex
GO:0045202
synapse
GO:0070062
extracellular exosome
GO:1990904
ribonucleoprotein complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:6ip6
,
PDBe:6ip6
,
PDBj:6ip6
PDBsum
6ip6
PubMed
31080011
UniProt
P62829
|RL23_HUMAN Large ribosomal subunit protein uL14 (Gene Name=RPL23)
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