Structure of PDB 8vtx Chain 2O

Receptor sequence
>8vtx2O (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRG
AVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFG
PVARELREKGFMKIVSLAPEVL
3D structure
PDB8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain2O
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 2O M1 Q3 Q5 T6 I22 R23 K26 G27 S28 N29 A30 K31 Y32 S42 K44 K66 K67 E68 K70 M1 Q3 Q5 T6 I22 R23 K26 G27 S28 N29 A30 K31 Y32 S42 K44 K66 K67 E68 K70
BS02 rna 2O N13 P48 R49 R97 N13 P48 R49 R97
External links
PDB RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum8vtx
PubMed39039256
UniProtQ5SHP8|RL14_THET8 Large ribosomal subunit protein uL14 (Gene Name=rplN)

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