Structure of PDB 6ip5 Chain 2J

Receptor sequence

>6ip52J (length=153) Species: 9606 (Homo sapiens)

VRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDV
TLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESN
AELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILT
EKE

3D structure

• PDB: 6ip5 HCV IRES Captures an Actively Translating 80S Ribosome.
• Chain: 2J
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2J	K16 S17 R18 S20 R23 H25 K27 R30 Q34 K37 R62 Y63 N64 G65 G66 G68 R69 A71 Q75 R82 W83 P84 K85 K86 F90 N101 H116 Q118 V119 R127 Y130 R131 A132 I136 P138 Y139 M140 S141	K15 S16 R17 S19 R22 H24 K26 R29 Q33 K36 R61 Y62 N63 G64 G65 G67 R68 A70 Q74 R81 W82 P83 K84 K85 F89 N100 H115 Q117 V118 R126 Y129 R130 A131 I135 P137 Y138 M139 S140
BS02	rna	2J	S5 R61 R62 P123	S4 R60 R61 P122

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ip5, PDBe:6ip5, PDBj:6ip5
• PDBsum: 6ip5
• PubMed: 31080011
• UniProt: P18621|RL17_HUMAN Large ribosomal subunit protein uL22 (Gene Name=RPL17)