Structure of PDB 8vty Chain 2H

Receptor sequence
>8vty2H (length=173) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
RIGRLPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVRV
ERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGRA
LELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAIR
KPSAYHEKGIYYAGEPVRLKPGK
3D structure
PDB8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain2H
Resolution2.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 2H R3 I4 R59 K62 S63 G66 L67 T70 F109 S110 H111 K138 Q139 G142 Q143 Y157 H158 K160 K175 R1 I2 R57 K60 S61 G64 L65 T68 F107 S108 H109 K136 Q137 G140 Q141 Y155 H156 K158 K173
External links
PDB RCSB:8vty, PDBe:8vty, PDBj:8vty
PDBsum8vty
PubMed39039256
UniProtP0DOY8|RL6_THET8 Large ribosomal subunit protein uL6 (Gene Name=rplF)

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