Structure of PDB 8vty Chain 2G

Receptor sequence

>8vty2G (length=181) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

3D structure

PDB

8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2G	K36 V38 N40 G42 L43 T71 A73 K75 I77 F80 I88 R91 S124 F125 D126 R128 N132 G134 L135 R136 G154 M155 D156 A158 V160	K35 V37 N39 G41 L42 T70 A72 K74 I76 F79 I87 R90 S123 F124 D125 R127 N131 G133 L134 R135 G153 M154 D155 A157 V159
BS02	rna	2G	N27 W29 E30 Q66 K67 A69 V70 R91 V92 T93 R95 R96	N26 W28 E29 Q65 K66 A68 V69 R90 V91 T92 R94 R95
BS03	MG	2G	R113 L139	R112 L138
BS04	MG	2G	R128 G129 N130 T161	R127 G128 N129 T160

External links

PDB	RCSB:8vty, PDBe:8vty, PDBj:8vty
PDBsum	8vty
PubMed	39039256
UniProt	Q5SHQ0\|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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