Structure of PDB 8vtx Chain 2G

Receptor sequence

>8vtx2G (length=181) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

3D structure

PDB

8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2G	K36 N40 G42 L43 E45 T71 A73 K74 N79 F80 I88 R91 S124 D126 R128 N132 L133 L135 R136 G154 D156	K35 N39 G41 L42 E44 T70 A72 K73 N78 F79 I87 R90 S123 D125 R127 N131 L132 L134 R135 G153 D155
BS02	rna	2G	P2 N27 V28 W29 Q66 K67 A69 V70 R91 V92 T93 R95 R96 R98	P1 N26 V27 W28 Q65 K66 A68 V69 R90 V91 T92 R94 R95 R97
BS03	rna	2G	S76 I77 S78	S75 I76 S77
BS04	MG	2G	R128 G129 N130 T161 A163	R127 G128 N129 T160 A162

External links

PDB	RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum	8vtx
PubMed	39039256
UniProt	Q5SHQ0\|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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