Structure of PDB 8uvr Chain 2G

Receptor sequence

>8uvr2G (length=181) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PLDVALKRKYYEEVRPELIRRFGYQNVWEVPRLEKVVINQGLGEAKEDAR
ILEKAAQELALITGQKPAVTRAKKSISNFKLRKGMPIGLRVTLRRDRMWI
FLEKLLNVALPRIRDFRGLNPNSFDGRGNYNLGLREQLIFPEITYDMVDA
LRGMDIAVVTTAETDEEARALLELLGFPFRK

3D structure

PDB

8uvr Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.

Chain

Resolution

2.6 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2G	N40 G42 L43 E45 T71 A73 K74 I77 F80 S124 F125 D126 R128 N132 G134 L135 G154 M155 D156 A158	N39 G41 L42 E44 T70 A72 K73 I76 F79 S123 F124 D125 R127 N131 G133 L134 G153 M154 D155 A157
BS02	rna	2G	N27 W29 Q66 K67 A69 V70 R91 V92 T93 R95 R96	N26 W28 Q65 K66 A68 V69 R90 V91 T92 R94 R95
BS03	rna	2G	S76 S78	S75 S77

External links

PDB	RCSB:8uvr, PDBe:8uvr, PDBj:8uvr
PDBsum	8uvr
PubMed	38165935
UniProt	Q5SHQ0\|RL5_THET8 Large ribosomal subunit protein uL5 (Gene Name=rplE)

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