Structure of PDB 6ip6 Chain 2F

Receptor sequence

>6ip62F (length=210) Species: 9606 (Homo sapiens)

APSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPA
SGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLILFPRKPSAPKKGDSSAEELKLATQLT
GPVMPVRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDVEKKK

3D structure

• PDB: 6ip6 HCV IRES Captures an Actively Translating 80S Ribosome.
• Chain: 2F
• Resolution: 4.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2F	S4 R5 M8 L10 K11 P12 H13 F14 H15 K16 D17 W18 Q19 Q28 R31 R35 R36 R39 K42 R56 V59 R60 C61 P62 Y66 R71 G73 R74 L78 K88 R92 D99 R101 R102 R103 K105 S106 K135 R158 F179 R183 R186 R198	S3 R4 M7 L9 K10 P11 H12 F13 H14 K15 D16 W17 Q18 Q27 R30 R34 R35 R38 K41 R55 V58 R59 C60 P61 Y65 R70 G72 R73 L77 K87 R91 D98 R100 R101 R102 K104 S105 K134 R157 F178 R182 R185 R197
BS02	rna	2F	N27 A30 R34	N26 A29 R33

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0001824 blastocyst development
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0060348 bone development

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ip6, PDBe:6ip6, PDBj:6ip6
• PDBsum: 6ip6
• PubMed: 31080011
• UniProt: P26373|RL13_HUMAN Large ribosomal subunit protein eL13 (Gene Name=RPL13)