Structure of PDB 4wzo Chain 29

Receptor sequence

>4wzo29 (length=205) Species: 300852 (Thermus thermophilus HB8)

MKGILGVKVGMTRIFRDDRAVPVTVILAGPCPVVQRRTPEKDGYTAVQLG
FLPQNPKRVNRPLKGHFAKAGVEPVRILREIRDFNPEGDTVTVEIFKPGE
RVDVTGTSKGRGFAGVMKRWNFAGGPDSHGAHKIHRHPGSIGNRKTPGRV
YKGKKMAGHYGAERVTVMNLEVVDVIPEENLLLVKGAVPGPNGGLVIVRE
TKKAA

3D structure

• PDB: 4wzo Structural insights into the translational infidelity mechanism.
• Chain: 29
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	29	M11 T12 R13 Q35 R37 D42 Y44 Q48 R58 R61 L63 K64 G65 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 K154 M156 A157 H159 Y160 R164 T166 M168 N169 L170 K185 A187 V188 P189 G190 P191 K202 A204	M11 T12 R13 Q35 R37 D42 Y44 Q48 R58 R61 L63 K64 G65 I77 L78 R79 E80 R82 S108 K109 G110 R111 G112 F113 G115 K118 R119 F122 A123 D127 S128 H129 G130 A131 H132 K133 I134 H135 R136 H137 G139 S140 I141 G142 N143 R144 K145 T146 P147 G148 R149 V150 Y151 K152 K154 M156 A157 H159 Y160 R164 T166 M168 N169 L170 K185 A187 V188 P189 G190 P191 K202 A204
BS02	MG	29	N121 Y160	N121 Y160

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4wzo, PDBe:4wzo, PDBj:4wzo
• PDBsum: 4wzo
• PubMed: 26037619
• UniProt: Q5SHN8|RL3_THET8 Large ribosomal subunit protein uL3 (Gene Name=rplC)