Structure of PDB 8fc4 Chain 23

Receptor sequence
>8fc423 (length=59) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
PRLKVKLVKSPIGYPKDQKAALKALGLRRLQQERVLEDTPAIRGNVEKVA
HLVRVEVVE
3D structure
PDB8fc4 Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.
Chain23
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 23 K10 S11 I13 G14 Y15 P16 K17 A21 A22 K24 A25 R29 R30 L31 Q32 P41 A42 G45 N46 K49 K9 S10 I12 G13 Y14 P15 K16 A20 A21 K23 A24 R28 R29 L30 Q31 P40 A41 G44 N45 K48
BS02 rna 23 Y15 H52 Y14 H51
BS03 MG 23 K10 S11 K9 S10
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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External links
PDB RCSB:8fc4, PDBe:8fc4, PDBj:8fc4
PDBsum8fc4
PubMed37452045
UniProtQ5SHQ6|RL30_THET8 Large ribosomal subunit protein uL30 (Gene Name=rpmD)

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