Structure of PDB 8aw3 Chain 2

Receptor sequence
>8aw32 (length=177) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
ESVVYCDVFMQAALKEATCALEEGEVPVGCVLVKADSSTAAQAQAGDDLA
LQKLIVARGRNATNRKGHGLAHAEFVAVEELLRQADLADYVLYVVVEPCI
MCAAMLLYNRVRKVYFGCTNPRFGGNGTVLSVHNSYKGLIGYESCGGYRA
EEAVVLLQQFYRRENTNAPLGKRKRKD
3D structure
PDB8aw3 Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
Chain2
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 2 V46 V133 E134 P135 C155 T156 N157 R159 F160 V198 L201 Q202 F204 Y205 E208 N209 N211 K216 K218 V28 V96 E97 P98 C118 T119 N120 R122 F123 V154 L157 Q158 F160 Y161 E164 N165 N167 K172 K174
BS02 ZN 2 H90 C136 C139 H72 C99 C102
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing

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Molecular Function
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Biological Process
External links
PDB RCSB:8aw3, PDBe:8aw3, PDBj:8aw3
PDBsum8aw3
PubMed36347890
UniProtQ57W17

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