Structure of PDB 7w1y Chain 2

Receptor sequence
>7w1y2 (length=706) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKE
NRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYD
RITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMV
KYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQR
IRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGS
LNTANGFPVFATVILANHVAKKDNGELTDEDVKMITSLSKDQQIGEKIFA
SIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAK
SQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLA
DRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAA
ANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFV
VGSHVRHHPSNKGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYS
DLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVM
LESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQR
NRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRK
MILQQF
3D structure
PDB7w1y The human pre-replication complex is an open complex.
Chain2
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 2 G359 P360 G184 P185
BS02 ZN 2 C329 C332 C355 C154 C157 C180
BS03 ATP 2 Y486 P525 G526 T527 A528 K529 S530 Q531 N631 L675 Y307 P346 G347 T348 A349 K350 S351 Q352 N452 L496
BS04 ADP 2 H511 V764 E768 H332 V566 E570
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0019899 enzyme binding
GO:0042393 histone binding
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006334 nucleosome assembly
GO:0006915 apoptotic process
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0071353 cellular response to interleukin-4
GO:0090102 cochlea development
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP49736|MCM2_HUMAN DNA replication licensing factor MCM2 (Gene Name=MCM2)

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