Structure of PDB 7nvw Chain 2

Receptor sequence
>7nvw2 (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
NLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLP
QAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLILNPIFRQNLRIALLG
GVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEP
PCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFS
DSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINQPGFIVVETNYRLYAY
TESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFL
RTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDF
ELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQ
3D structure
PDB7nvw Structures of mammalian RNA polymerase II pre-initiation complexes.
Chain2
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 2 D389 L396 D321 L328
Gene Ontology
Molecular Function
GO:0001671 ATPase activator activity
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nvw, PDBe:7nvw, PDBj:7nvw
PDBsum7nvw
PubMed33902107
UniProtQ92759|TF2H4_HUMAN General transcription factor IIH subunit 4 (Gene Name=GTF2H4)

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