Structure of PDB 6u0m Chain 2

Receptor sequence
>6u0m2 (length=634) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLA
ESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGP
FFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPG
RLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATI
IEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISS
MAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKS
QILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAA
NPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVV
DSHVRSQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVS
SYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIY
3D structure
PDB6u0m DNA unwinding mechanism of a eukaryotic replicative CMG helicase.
Chain2
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP 2 I505 G546 T547 A548 K549 S550 L695 I305 G346 T347 A348 K349 S350 L495
BS02 ATP 2 H531 E625 R676 V807 R808 E811 H331 E425 R476 V577 R578 E581
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6u0m, PDBe:6u0m, PDBj:6u0m
PDBsum6u0m
PubMed
UniProtP29469|MCM2_YEAST DNA replication licensing factor MCM2 (Gene Name=MCM2)

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