Structure of PDB 6rfq Chain 2

Receptor sequence
>6rfq2 (length=469) Species: 4952 (Yarrowia lipolytica) [Search protein sequence]
MLILAIISLITFVSMSKLSDNRAIIRLINIYLILVLVLDSFLYLLFLNNQ
TYTVMGELLIFNSFTFYIDMLIYFIMIVISSLYGYNLYNNNLYKTLFEPK
KELIILFLINILGALLIVHSNDFITLFVAIELQSYSIYLITAIYNSSYKA
SKASMLYFFMGGILSILIAYSINTYYSVLNSYTLHSLDSLIINTLDLNLI
LIALSLGLLFKIGIAPLHKWLISIYENTPILITIYISLIPKISILSYLVL
SNISINSLVISILAILTLLVGSVGGLLQIKIKRLLAFSGLTNAGYMMLLL
LLNNNEFSYLYYITQYSISHLAIFMIIIFSIYYINYINNQYNPIIYVNQL
KGLIHDNAYLVLSMAIVVFSFIGIPPLLGFFGKLNILMSILNNGYYFISI
VLIVASLISALYYLYLLNVSIQDKNNILINSNETVSSVLSYILSSLIILI
TFGFIYNSLIIDIFNVYFN
3D structure
PDB6rfq High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease.
Chain2
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T7X 2 F74 Y85 S437 V438 Y441 S445 F74 Y85 S437 V438 Y441 S445
BS02 CPL 2 S40 Y43 Y67 F74 Y311 T314 L378 Y456 I460 I463 S40 Y43 Y67 F74 Y311 T314 L378 Y456 I460 I463
BS03 T7X 2 I166 L167 L199 I202 L206 N256 S257 L258 I166 L167 L199 I202 L206 N256 S257 L258
BS04 T7X 2 L407 L411 L407 L411
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rfq, PDBe:6rfq, PDBj:6rfq
PDBsum6rfq
PubMed31844670
UniProtQ9B6C8|NU2M_YARLI NADH-ubiquinone oxidoreductase chain 2 (Gene Name=ND2)

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