Structure of PDB 6raz Chain 2

Receptor sequence
>6raz2 (length=559) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
LGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLA
NKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISLP
LIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKNMEQTLYR
NYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNN
YDGSLNTDQGFPVFATVIIANHVVVKDSKQVDIATIQKLSKDPRIVERVV
ASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTA
KSQFLKYTEKVAPRAVFTTGQGASAVGLYVRRNPVSREWTLEAGALVLAD
QGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAA
NPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFQLAKFVVHSHMKH
HEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPI
TVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMK
KMRSTFQKY
3D structure
PDB6raz Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain2
Resolution4.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP 2 R641 R742 R426 R503
BS02 ADP 2 I470 S515 Q516 I257 S302 Q303
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0030261 chromosome condensation
GO:0032508 DNA duplex unwinding
GO:0051301 cell division
GO:1902975 mitotic DNA replication initiation
GO:1905775 negative regulation of DNA helicase activity
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raz, PDBe:6raz, PDBj:6raz
PDBsum6raz
PubMed31484077
UniProtP49735|MCM2_DROME DNA replication licensing factor Mcm2 (Gene Name=Mcm2)

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