Structure of PDB 5xjl Chain 2

Receptor sequence
>5xjl2 (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
EELMPRLLPVTPQEYLRRVQIEAAQCPDVVVAQIDPKQSVNISLSGCQPA
PEGYSPTLQWQQQQVAQFSTVRQNVNKHRSHWMPKSEDEEGWKKFCLGEI
GFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEK
PLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRD
LADE
3D structure
PDB5xjl Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly
Chain2
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 2 W102 Q105 Q106 Q109 P178 L179 L180 S181 G212 R213 Y216 P257 N260 W60 Q63 Q64 Q67 P104 L105 L106 S107 G138 R139 Y142 P183 N186
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000387 spliceosomal snRNP assembly
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1905215 negative regulation of RNA binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0097504 Gemini of coiled bodies

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xjl, PDBe:5xjl, PDBj:5xjl
PDBsum5xjl
PubMed21816274
UniProtO14893|GEMI2_HUMAN Gem-associated protein 2 (Gene Name=GEMIN2)

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