Structure of PDB 5mei Chain 2

Receptor sequence

>5mei2 (length=159) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

GKSHGYRSRTRYMFQRDFRKHGAVHLSTYLKVYKVGDIVDIKANGSIQKG
MPHKFYQGKTGVVYNVTKSSVGVIINKMVGNRYLEKRLNLRVEHIKHSKC
RQEFLERVKANAAKRAEAKAQGVAVQLKRQPAQPRESRIVSTEGNVPQTL
APVPYETFI

3D structure

PDB

5mei Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2	G2 K3 S4 H5 G6 Y7 R8 S9 R10 R12 Y13 M14 Q16 R17 F19 H22 G23 K35 D41 S47 Q49 G51 H54 K55 Y57 Q58 G59 K60 T61 T68 K69 S70 S71 K78 V80 N82 R83 K87 R88 N90 R92 K100 C101 R102 E104 F105 R108 R116 K120 Q127 L128 K129 R130 P132	G1 K2 S3 H4 G5 Y6 R7 S8 R9 R11 Y12 M13 Q15 R16 F18 H21 G22 K34 D40 S46 Q48 G50 H53 K54 Y56 Q57 G58 K59 T60 T67 K68 S69 S70 K77 V79 N81 R82 K86 R87 N89 R91 K99 C100 R101 E103 F104 R107 R115 K119 Q126 L127 K128 R129 P131
BS02	rna	2	R20 H26 S28	R19 H25 S27
BS03	OHX	2	Y13 D18	Y12 D17

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5mei, PDBe:5mei, PDBj:5mei
PDBsum	5mei
PubMed	28457705
UniProt	Q02753\|RL21A_YEAST Large ribosomal subunit protein eL21A (Gene Name=RPL21A)

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