Structure of PDB 4eu2 Chain 2

Receptor sequence
>4eu22 (length=233) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTV
VGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVM
YQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHM
ANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAII
DKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
3D structure
PDB4eu2 Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.
Chain2
Resolution2.509 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WPI 2 Q-6 P-5 Y22 R182 Q3 P4 Y30 R190
Gene Ontology
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4eu2, PDBe:4eu2, PDBj:4eu2
PDBsum4eu2
PubMed23593271
UniProtP30657|PSB7_YEAST Proteasome subunit beta type-7 (Gene Name=PRE4)

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