Structure of PDB 1c4v Chain 2

Receptor sequence
>1c4v2 (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1c4v Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Chain2
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 2 F34 K36 Q38 L65 R67 R73 T74 R75 Y76 K81 I82 M84 F19 K21 Q24 L60 R62 R68 T69 R70 Y71 K77 I78 M80
BS02 IH2 2 H57 Y60A W60D N98 I174 D189 A190 S195 V213 S214 W215 G216 E217 H43 Y47 W50 N95 I172 D192 A193 S198 V218 S219 W220 G221 E222 MOAD: Ki=0.016nM
PDBbind-CN: -logKd/Ki=10.80,Ki=0.016nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1c4v, PDBe:1c4v, PDBj:1c4v
PDBsum1c4v
PubMed10713516
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

[Back to BioLiP]