Structure of PDB 1c4u Chain 2

Receptor sequence
>1c4u2 (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
3D structure
PDB1c4u Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.
Chain2
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 2 F34 Q38 L40 R67 R73 T74 R75 Y76 K81 I82 F19 Q24 L26 R62 R68 T69 R70 Y71 K77 I78
BS02 IH1 2 H57 Y60A W60D E97A N98 L99 D189 A190 S214 W215 G216 G219 H43 Y47 W50 E94 N95 L96 D192 A193 S219 W220 G221 G223 MOAD: Ki=0.043nM
PDBbind-CN: -logKd/Ki=10.37,Ki=0.043nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1c4u, PDBe:1c4u, PDBj:1c4u
PDBsum1c4u
PubMed10713516
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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