Structure of PDB 8vtu Chain 1t

Receptor sequence

>8vtu1t (length=96) Species: 300852 (Thermus thermophilus HB8)

RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMR
KAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGG

3D structure

• PDB: 8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 1t
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1t	K14 R15 H16 R17 Q18 S19 K21 R22 R23 A28 K29 S31 K34 T35 L36 K39 E51 K54 R57 E60 S61 D64 K68 S70 H73 K74 N75 A78 R79 K81 S82 R83 M85 R89 G102 G103	K7 R8 H9 R10 Q11 S12 K14 R15 R16 A21 K22 S24 K27 T28 L29 K32 E44 K47 R50 E53 S54 D57 K61 S63 H66 K67 N68 A71 R72 K74 S75 R76 M78 R82 G95 G96
BS02	MG	1t	A67 G69 L72	A60 G62 L65

External links

• PDB: RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
• PDBsum: 8vtu
• PubMed: 39039256
• UniProt: P80380|RS20_THET8 Small ribosomal subunit protein bS20 (Gene Name=rpsT)