Structure of PDB 8uvs Chain 1m

Receptor sequence

>8uvs1m (length=123) Species: 300852 (Thermus thermophilus HB8)

ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTVAGKKKAP

3D structure

• PDB: 8uvs Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
• Chain: 1m
• Resolution: 2.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1m	K79 D83 R93	K78 D82 R92
BS02	rna	1m	K13 R14 V17 Y21 Y23 G24 I25 G26 A28 R29 R44 N77 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 K111 R114 K115 T116 V117	K12 R13 V16 Y20 Y22 G23 I24 G25 A27 R28 R43 N76 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 K110 R113 K114 T115 V116
BS03	rna	1m	A123 P124	A122 P123
BS04	rna	1m	T116 A118 G119	T115 A117 G118
BS05	MG	1m	T20 I22 I25	T19 I21 I24

External links

• PDB: RCSB:8uvs, PDBe:8uvs, PDBj:8uvs
• PDBsum: 8uvs
• PubMed: 38165935
• UniProt: P80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)