Structure of PDB 7rqd Chain 1m

Receptor sequence

>7rqd1m (length=116) Species: 300852 (Thermus thermophilus HB8)

ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTV

3D structure

• PDB: 7rqd Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
• Chain: 1m
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1m	K13 V17 Y21 Y23 G24 I25 G26 A28 R29 R44 V74 N77 Y87 R88 R91 H92 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 R110 K111 K115	K12 V16 Y20 Y22 G23 I24 G25 A27 R28 R43 V73 N76 Y86 R87 R90 H91 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 R109 K110 K114
BS02	MG	1m	G100 Q101	G99 Q100
BS03	MG	1m	I22 Y23	I21 Y22

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7rqd, PDBe:7rqd, PDBj:7rqd
• PDBsum: 7rqd
• PubMed: 35165455
• UniProt: P80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)