Structure of PDB 6xqe Chain 1m

Receptor sequence

>6xqe1m (length=122) Species: 300852 (Thermus thermophilus HB8)

ARIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEA
EVVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQ
RTRTNARTRKGPRKTVAGKKKA

3D structure

• PDB: 6xqe Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome.
• Chain: 1m
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1m	D83 R93	D82 R92
BS02	rna	1m	K13 R14 Y21 I22 Y23 G24 I25 G26 A28 R29 R44 V74 N77 I78 Y87 R88 R91 L96 P97 V98 R99 Q101 R102 T103 R104 T105 N106 A107 R108 T109 K111 R114 K115 T116 K120	K12 R13 Y20 I21 Y22 G23 I24 G25 A27 R28 R43 V73 N76 I77 Y86 R87 R90 L95 P96 V97 R98 Q100 R101 T102 R103 T104 N105 A106 R107 T108 K110 R113 K114 T115 K119
BS03	MG	1m	Q101 R102	Q100 R101

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xqe, PDBe:6xqe, PDBj:6xqe
• PDBsum: 6xqe
• PubMed: 32817463
• UniProt: P80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)