Structure of PDB 8vtw Chain 1l

Receptor sequence

>8vtw1l (length=122) Species: 300852 (Thermus thermophilus HB8)

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK

3D structure

• PDB: 8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 1l
• Resolution: 2.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1l	P5 T6 N8 Q9 R12 R15 E16 V24 P31 F32 R33 R34 K46 K47 N49 S50 A51 R53 K54 T61 Y69 E73 L84 R86 G87 V90 K91 X92 P94 R97 R113 K114 K115 S116 R117 S118 K119 T122 K123 K124	P1 T2 N4 Q5 R8 R11 E12 V20 P27 F28 R29 R30 K42 K43 N45 S46 A47 R49 K50 T57 Y65 E69 L80 R82 G83 V86 K87 X88 P90 R93 R109 K110 K111 S112 R113 S114 K115 T118 K119 K120
BS02	MG	1l	P48 N49	P44 N45

External links

• PDB: RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
• PDBsum: 8vtw
• PubMed: 39039256
• UniProt: Q5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)