Structure of PDB 8vtw Chain 1i

Receptor sequence

>8vtw1i (length=127) Species: 300852 (Thermus thermophilus HB8)

EQYYGTGRRKEAVARVFLRPGNGKVTVNGQDFNEYFQGLVRAVAALEPLR
AVDALGHFDAYITVRGGGKSGQIDAIKLGIARALVQYNPDYRAKLKPLGF
LTRDARVVERKKYGKHKARRAPQYSKR

3D structure

• PDB: 8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 1i
• Resolution: 2.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1i	Q3 Y5 T7 R9 R10 K11 E12 V14 R16 F18 R20 Y36 Q38 G39 Y62 R66 G67 G68 G69 K70 S71 Q73 R93 K97 T103 R104 R107 V108 V109 E110 R111 K112 K113 Y114 G115 H117 K118 R120 R121 A122 P123 Q124 Y125 K127	Q2 Y4 T6 R8 R9 K10 E11 V13 R15 F17 R19 Y35 Q37 G38 Y61 R65 G66 G67 G68 K69 S70 Q72 R92 K96 T102 R103 R106 V107 V108 E109 R110 K111 K112 Y113 G114 H116 K117 R119 R120 A121 P122 Q123 Y124 K126

External links

• PDB: RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
• PDBsum: 8vtw
• PubMed: 39039256
• UniProt: P80374|RS9_THET8 Small ribosomal subunit protein uS9 (Gene Name=rpsI)