Structure of PDB 8vtw Chain 1h

Receptor sequence

>8vtw1h (length=137) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

LTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYERV
DVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEIP
RVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW

3D structure

PDB

8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.35 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1h	L2 T3 A7 D8 T11 R12 R14 N15 K21 S29 F31 K56 R75 K88 P89 G90 R91 R92 Y94 G96 V97 K98 R102 R105 S113 T114 S115 G128 V129 G130 E132	L1 T2 A6 D7 T10 R11 R13 N14 K20 S28 F30 K55 R74 K87 P88 G89 R90 R91 Y93 G95 V96 K97 R101 R104 S112 T113 S114 G127 V128 G129 E131

External links

PDB	RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum	8vtw
PubMed	39039256
UniProt	P0DOY9\|RS8_THET8 Small ribosomal subunit protein uS8 (Gene Name=rpsH)