Structure of PDB 8vtw Chain 1c

Receptor sequence

>8vtw1c (length=206) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG
LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL
NVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKV
IVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAY
IFLGEV

3D structure

PDB

8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.35 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1c	G2 N3 K4 I5 F10 K26 K27 S154 G155 R156 E161 Q162 A163 W167 G171 R172 V173 L175 H176 T177 L178 R179 F186 T192 Y193 G194 V195 G197 K199	G1 N2 K3 I4 F9 K25 K26 S153 G154 R155 E160 Q161 A162 W166 G170 R171 V172 L174 H175 T176 L177 R178 F185 T191 Y192 G193 V194 G196 K198

External links

PDB	RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum	8vtw
PubMed	39039256
UniProt	P80372\|RS3_THET8 Small ribosomal subunit protein uS3 (Gene Name=rpsC)

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