Structure of PDB 8vtu Chain 1Y

Receptor sequence

>8vtu1Y (length=107) Species: 300852 (Thermus thermophilus HB8)

MRVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVR
VSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCA
KCGGALD

3D structure

• PDB: 8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 1Y
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1Y	M1 K4 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 R50 V51 G58 G59 F60 H68 S70 K71 R73 R84 R86 K87 K95	M1 K4 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 R50 V51 G58 G59 F60 H68 S70 K71 R73 R84 R86 K87 K95
BS02	MG	1Y	R2 K4	R2 K4
BS03	MG	1Y	I38 V39 V42	I38 V39 V42
BS04	ZN	1Y	C76 C79 C99 C102	C76 C79 C99 C102

External links

• PDB: RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
• PDBsum: 8vtu
• PubMed: 39039256
• UniProt: Q5SHP9|RL24_THET8 Large ribosomal subunit protein uL24 (Gene Name=rplX)