Structure of PDB 5j4c Chain 1Y

Receptor sequence

>5j4c1Y (length=107) Species: 300852 (Thermus thermophilus HB8)

MRVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVR
VSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCA
KCGGALD

3D structure

• PDB: 5j4c Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
• Chain: 1Y
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1Y	M1 R2 K4 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95	M1 R2 K4 K8 K9 S17 G18 K19 K21 V30 P32 Y35 K46 K47 A48 V49 V51 G59 F60 K63 H68 S70 K71 R73 R84 R86 K87 K95
BS02	ZN	1Y	C76 C79 C99 C102	C76 C79 C99 C102
BS03	MG	1Y	V39 V42 A65 L67	V39 V42 A65 L67

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5j4c, PDBe:5j4c, PDBj:5j4c
• PDBsum: 5j4c
• PubMed: 27079977
• UniProt: Q5SHP9|RL24_THET8 Large ribosomal subunit protein uL24 (Gene Name=rplX)