Structure of PDB 8vtv Chain 1X

Receptor sequence

>8vtv1X (length=95) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MKTAYDVILAPVLSEKAYAGFAEGKYTFWVHPKATKTEIKNAVETAFKVK
VVKVNTLHVRGKKKRLGRYLGKRPDRKKAIVQVAPGQKIEALEGL

3D structure

PDB

8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.55 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1X	S14 K16 K25 T35 K36 T37 K40 K53 N55 T56 L57 H58 R60 K62 K63 K64 L66 R68 Y69 L70 G71 K72 R73 D75 K78 I80	S14 K16 K25 T35 K36 T37 K40 K53 N55 T56 L57 H58 R60 K62 K63 K64 L66 R68 Y69 L70 G71 K72 R73 D75 K78 I80
BS02	MG	1X	T56 K77	T56 K77
BS03	MG	1X	R76 K77	R76 K77
BS04	MG	1X	P74 R76	P74 R76
BS05	MG	1X	V59 R60 G61 D75 R76	V59 R60 G61 D75 R76
BS06	MG	1X	A17 F21 K25 Y26 T27	A17 F21 K25 Y26 T27

External links

PDB	RCSB:8vtv, PDBe:8vtv, PDBj:8vtv
PDBsum	8vtv
PubMed	39039256
UniProt	Q5SHP0\|RL23_THET8 Large ribosomal subunit protein uL23 (Gene Name=rplW)