Structure of PDB 8fc5 Chain 1W

Receptor sequence

>8fc51W (length=112) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKV
LESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRT
SHITVILGEKHG

3D structure

PDB

8fc5 Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.

Chain

Resolution

2.65 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1W	K4 A5 I6 A7 R8 Y9 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 P80 K83 R84 P87 R88 A89 R90 R92 A93 D94 K97 K98 R99 H102	K4 A5 I6 A7 R8 Y9 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 S53 A56 N57 N60 N61 H62 Y75 D77 E78 P80 K83 R84 P87 R88 A89 R90 R92 A93 D94 K97 K98 R99 H102
BS02	MG	1W	I95 K97	I95 K97

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8fc5, PDBe:8fc5, PDBj:8fc5
PDBsum	8fc5
PubMed	37452045
UniProt	Q5SHP3\|RL22_THET8 Large ribosomal subunit protein uL22 (Gene Name=rplV)