Structure of PDB 8vtv Chain 1V

Receptor sequence

>8vtv1V (length=101) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MFAIVKTGGKQYRVEPGLKLRVEKLDAEPGATVELPVLLLGGEKTVVGTP
VVEGASVVAEVLGHGRGKKILVSKFKAKVQYRRKKGHRQPYTELLIKEIR
G

3D structure

PDB

8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.55 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1V	G8 G9 K10 L18 E23 K24 K69 V72 K74 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 Q89	G8 G9 K10 L18 E23 K24 K69 V72 K74 A77 K78 V79 Q80 Y81 R82 R83 K84 K85 G86 H87 Q89
BS02	MG	1V	K84 K85	K84 K85
BS03	MG	1V	K78 Q80	K78 Q80
BS04	MG	1V	V72 S73	V72 S73
BS05	MG	1V	K76 V79 Q80 R82	K76 V79 Q80 R82
BS06	MG	1V	E23 K24 P90	E23 K24 P90

External links

PDB	RCSB:8vtv, PDBe:8vtv, PDBj:8vtv
PDBsum	8vtv
PubMed	39039256
UniProt	P60492\|RL21_THET8 Large ribosomal subunit protein bL21 (Gene Name=rplU)