Structure of PDB 8vtx Chain 1U

Receptor sequence

>8vtx1U (length=116) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PRAKTGVVRRRKHKKILKLAKGYWGLRSKSFRKARETLFAAGNYAYAHRK
RRKRDFRRLWIVRINAACRQHGLNYSTFIHGLKKAGIEVDRKNLADLAVR
EPQVFAELVERAKAAQ

3D structure

PDB

8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1U	P2 R3 A4 K5 T6 G7 R10 R11 R12 K13 H14 K15 K16 K19 G23 Y24 W25 G26 L27 R28 K30 S31 F32 R33 K34 R36 E37 A42 Y45 A46 Y47 H49 R50 K51 R52 R53 K54 R55 F57 R58 R59 W61 I62 V63 N66 R70 N75 Y76 S77 H81 D91 R92 K93	P1 R2 A3 K4 T5 G6 R9 R10 R11 K12 H13 K14 K15 K18 G22 Y23 W24 G25 L26 R27 K29 S30 F31 R32 K33 R35 E36 A41 Y44 A45 Y46 H48 R49 K50 R51 R52 K53 R54 F56 R57 R58 W60 I61 V62 N65 R69 N74 Y75 S76 H80 D90 R91 K92
BS02	MG	1U	G7 V8 R10 R11	G6 V7 R9 R10
BS03	MG	1U	Y47 R50 K51	Y46 R49 K50
BS04	MG	1U	G26 K30	G25 K29
BS05	MG	1U	V63 A67	V62 A66
BS06	MG	1U	L18 S29	L17 S28
BS07	MG	1U	K5 T6 G7	K4 T5 G6
BS08	MG	1U	F40 G43 N44	F39 G42 N43
BS09	MG	1U	G43 Y47 R50	G42 Y46 R49

External links

PDB	RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum	8vtx
PubMed	39039256
UniProt	P60491\|RL20_THET8 Large ribosomal subunit protein bL20 (Gene Name=rplT)