Structure of PDB 8vtw Chain 1Q

Receptor sequence

>8vtw1Q (length=141) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAA
RVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPG
RVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEAQ

3D structure

PDB

8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.35 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1Q	P4 R5 R6 K8 Y9 K11 Q13 R14 G15 R16 K18 K22 G24 Y26 F29 W41 Q46 A49 R56 R59 R60 R67 F69 D71 Y74 K76 K77 E80 R82 M83 G84 K85 G86 K87 R101 R119 H123 K124 L125 P126 K128	P4 R5 R6 K8 Y9 K11 Q13 R14 G15 R16 K18 K22 G24 Y26 F29 W41 Q46 A49 R56 R59 R60 R67 F69 D71 Y74 K76 K77 E80 R82 M83 G84 K85 G86 K87 R101 R119 H123 K124 L125 P126 K128
BS02	rna	1Q	R16 L17 G19	R16 L17 G19
BS03	MG	1Q	T75 K76 G88	T75 K76 G88
BS04	MG	1Q	G84 G86	G84 G86
BS05	MG	1Q	R14 Y74 T75	R14 Y74 T75
BS06	MG	1Q	T21 V97 R101	T21 V97 R101

External links

PDB	RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
PDBsum	8vtw
PubMed	39039256
UniProt	P60489\|RL16_THET8 Large ribosomal subunit protein uL16 (Gene Name=rplP)