Structure of PDB 8vtu Chain 1P

Receptor sequence

>8vtu1P (length=149) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MKLSDLRPNPGANKRRKRVGRGPGSGHGKTATRGHKGQKSRSGGLKDPRR
FEGGRSTTLMRLPKRGMQGQVPGEIKRPRYQGVNLKDLARFEGEVTPELL
VRAGLLKKGYRLKILGEGEAKPLKVVAHAFSKSALEKLKAAGGEPVLLE

3D structure

PDB

8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1P	L3 S4 R7 N9 A12 N13 K14 R16 K17 R18 V19 G20 R21 G22 P23 G24 S25 G28 K29 T30 A31 T32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 L45 K46 R50 F51 E52 G53 G54 R55 S56 M60 R61 P63 K64 R65 G66 M67 Q70 V71 P72 G73 E74 I75 K76 R77 Q81 N84 R90 G104 K107 K108 K113 L115 G116 S131 K132 S133	L3 S4 R7 N9 A12 N13 K14 R16 K17 R18 V19 G20 R21 G22 P23 G24 S25 G28 K29 T30 A31 T32 R33 G34 H35 K36 Q38 K39 S40 R41 S42 G43 L45 K46 R50 F51 E52 G53 G54 R55 S56 M60 R61 P63 K64 R65 G66 M67 Q70 V71 P72 G73 E74 I75 K76 R77 Q81 N84 R90 G104 K107 K108 K113 L115 G116 S131 K132 S133
BS02	MG	1P	G22 G24 S25	G22 G24 S25
BS03	MG	1P	R33 K39	R33 K39
BS04	MG	1P	G34 H35 K36 S40	G34 H35 K36 S40
BS05	MG	1P	H27 A31 T32	H27 A31 T32

External links

PDB	RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum	8vtu
PubMed	39039256
UniProt	Q5SHQ7\|RL15_THET8 Large ribosomal subunit protein uL15 (Gene Name=rplO)

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