Structure of PDB 8vtx Chain 1O

Receptor sequence

>8vtx1O (length=122) Species: 300852 (Thermus thermophilus HB8)

MIQPQTYLEVADNTGARKIMCIRVLKGSNAKYATVGDVIVASVKEAIPRG
AVKEGDVVKAVVVRTKKEIKRPDGSAIRFDDNAAVIINNQLEPRGTRVFG
PVARELREKGFMKIVSLAPEVL

3D structure

• PDB: 8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 1O
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	1O	M1 Q3 Q5 T6 Y7 I22 R23 L25 G27 S28 N29 A30 K31 Y32 S42 K44 V57 K67 E68 K70 N82	M1 Q3 Q5 T6 Y7 I22 R23 L25 G27 S28 N29 A30 K31 Y32 S42 K44 V57 K67 E68 K70 N82
BS02	rna	1O	N13 P48 R49 T96 R97 R107	N13 P48 R49 T96 R97 R107
BS03	MG	1O	R49 G50	R49 G50
BS04	MG	1O	D12 I86 P93 R94 G95	D12 I86 P93 R94 G95

External links

• PDB: RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
• PDBsum: 8vtx
• PubMed: 39039256
• UniProt: Q5SHP8|RL14_THET8 Large ribosomal subunit protein uL14 (Gene Name=rplN)