Structure of PDB 8vtu Chain 1N

Receptor sequence

>8vtu1N (length=140) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MKTYVPKQVEPRWVLIDAEGKTLGRLATKIATLLRGKHRPDWTPNVAMGD
FVVVVNADKIRVTGKKLEQKIYTRYSGYPGGLKKIPLEKMLATHPERVLE
HAVKGMLPKGPLGRRLFKRLKVYAGPDHPHQAQRPEKLEV

3D structure

PDB

8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	1N	K2 T3 W13 T22 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 K70 R74 Y75 S76 Y78 P79 G80 L82 K83 H94 R97 E100 H101 A102 G105 M106 P111 L112 R114 K118 H130 Q133	K2 T3 W13 T22 G24 R25 T28 R35 K37 N45 F51 T63 K65 K66 K70 R74 Y75 S76 Y78 P79 G80 L82 K83 H94 R97 E100 H101 A102 G105 M106 P111 L112 R114 K118 H130 Q133
BS02	MG	1N	G64 K65 L67	G64 K65 L67
BS03	MG	1N	R25 L26 K29	R25 L26 K29
BS04	MG	1N	R35 A47 M48 L116	R35 A47 M48 L116

External links

PDB	RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum	8vtu
PubMed	39039256
UniProt	P60488\|RL13_THET8 Large ribosomal subunit protein uL13 (Gene Name=rplM)